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[Optic nerve gliomas: a study of 11 cases]
L F Torres1, B C Medeiros, L Noronha
1Seção de Microscopia Eletrônica e Neuropatologia, Universidade Federal do Paraná, Curitiba.
Arquivos De Neuro-Psiquiatria
|June 1, 1996
Summary
Optic nerve gliomas are rare tumors, often pilocytic astrocytomas. This study reviewed 11 cases, finding a female predominance and association with neurofibromatosis in some patients.
Area of Science:
- Neuro-oncology
- Ophthalmology
- Pediatric Oncology
Context:
- Optic nerve gliomas (ONGs) are rare tumors, comprising 2-5% of intracranial and 6% of intraorbital neoplasms.
- These tumors can occur independently or as part of neurofibromatosis.
- Pilocytic astrocytoma is the common histopathological type observed in ONG cases.
Purpose:
- To analyze the clinical characteristics and outcomes of optic nerve gliomas.
- To report a series of 11 optic nerve glioma cases diagnosed in Curitiba over 25 years.
Summary:
- The study presents 11 cases of optic nerve gliomas, predominantly affecting females (10/11) aged 3-25 years.
- Neurofibromatosis was associated in 27.3% of cases (3/11).
- Tumor extension varied, with some cases involving the optic chiasm and adjacent brain regions; all were pilocytic astrocytomas.
Impact:
- This case series contributes to understanding the epidemiology and clinical presentation of optic nerve gliomas in a specific geographic region.
- Highlights the importance of considering neurofibromatosis in the diagnosis and management of optic nerve gliomas.
- Provides data on tumor extent and histopathology, aiding in prognosis and treatment planning for these rare pediatric and adult tumors.