Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on immunity to mouse sarcomas using the tumor-cell neutralization test

H C Thomas, K E Hellström, M A Kall

    Transactions. Section on Otolaryngology. American Academy of Ophthalmology and Otolaryngology
    |March 1, 1977
    PubMed
    Summary

    This study refines statistical analysis for tumor-cell neutralization (Winn) tests. It found that in vitro sensitized lymphocytes, compared to immune ones, facilitated tumor growth rate.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The expanding fireball of Nova Delphini 2013.

    Nature·2014
    Same author

    The role of worker participation in effective training.

    New solutions : a journal of environmental and occupational health policy : NS·2012
    Same author

    Optimal combinations of ultrasound-based and serum markers of disease severity in patients with chronic hepatitis C.

    Journal of viral hepatitis·2009
    Same author

    Veterinary pathology and peer review.

    Veterinary pathology·2009
    Same author

    Imaging the surface of Altair.

    Science (New York, N.Y.)·2007
    Same author

    Non-invasive evaluation of hepatic fibrosis using magnetic resonance and ultrasound techniques.

    Gut·2006

    Area of Science:

    • Immunology
    • Biostatistics
    • Oncology

    Background:

    • Tumor-cell neutralization (Winn) tests are crucial for evaluating anti-tumor immunity.
    • Existing statistical methods may not fully capture the nuances of Winn test outcomes.
    • A refined analytical approach is needed to better interpret these complex immunological assays.

    Purpose of the Study:

    • To present a refined statistical analysis for tumor-cell neutralization (Winn) tests.
    • To apply this analysis to compare in vitro sensitized lymphocytes with specifically immune lymphocytes.
    • To explore the impact of different lymphocyte preparations on tumor growth dynamics.

    Main Methods:

    • Utilized three key variables: tumor incidence, time to palpable tumor, and tumor growth rate.

    Related Experiment Videos

  • Employed the concept of relative risk and the Z statistic for analyzing time-dependent variables.
  • Applied the refined statistical model to experimental data comparing lymphocyte groups.

    • Main Results:

    • The refined statistical analysis provided a more comprehensive evaluation of Winn test results.
    • In vitro sensitized lymphocytes were observed to facilitate tumor growth rate compared to specifically immune lymphocytes.
    • The analysis quantified differences in tumor incidence and growth kinetics between experimental groups.

    Conclusions:

    • The developed statistical framework offers enhanced insights into tumor-host interactions during Winn tests.
    • In vitro sensitization protocols may yield lymphocytes that promote, rather than inhibit, tumor growth.
    • This analytical approach has broader applications for interpreting immunological assays in cancer research.