Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Acute radiation thyroiditis

K Nishiyama¹, T Kozuka, T Higashihara

¹Department of Radiology, Kinki Central Hospital, Itami, Japan.

International Journal of Radiation Oncology, Biology, Physics

|December 1, 1996

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability.

Science advances·2021

Same author

Corrigendum to "Antithrombotic therapy trends in non-valvular atrial fibrillation patients undergoing percutaneous coronary stent implantation: Results from a survey among fellows at the Japanese College of Cardiology" [J. Cardiol. 72 (2) (2018) 113-119].

Journal of cardiology·2018

Same author

Long-term clinical impact of serum albumin in coronary artery disease patients with preserved renal function.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2018

Same author

Effects of lipopolysaccharide (LPS) and peptidoglycan (PGN) on estradiol production in bovine granulosa cells from small and large follicles.

Toxicology in vitro : an international journal published in association with BIBRA·2012

Same author

Protein transduction by pseudotyped lentivirus-like nanoparticles.

Gene therapy·2011

Same author

Pathological fracture of the mandible resulting from osteomyelitis successfully treated with only intermaxillary elastic guiding.

International journal of oral and maxillofacial surgery·2008

External neck irradiation can cause acute thyroid dysfunction, including a temporary thyrotoxic phase followed by hypothyroidism. This study assessed thyroid function changes in patients receiving radiation therapy.

Area of Science:

Endocrinology
Oncology
Radiology

Background:

Radiation-induced thyroid dysfunction is typically viewed as a late complication.
Acute thyroid reactions to external neck irradiation are less understood.

Purpose of the Study:

To prospectively evaluate acute thyroidal reactions following external neck irradiation.
To assess changes in thyroid function tests during and after radiotherapy.

Main Methods:

Prospective study of 22 patients with incidental thyroid exposure to therapeutic radiation doses.
Thyroid function tests (TSH, T3, T4, thyroglobulin, antibodies) measured at baseline, during, and at multiple time points post-radiotherapy.

Main Results:

Serum TSH levels showed a biphasic pattern: a significant decrease during radiotherapy (thyrotoxic phase) followed by a significant increase (hypothyroid phase).

Related Experiment Videos

Thyroid hormone levels increased subtly during radiotherapy.

TSH suppression during radiation correlates with increased thyroid hormone release.

Conclusions:

External neck irradiation can induce both acute thyrotoxicosis and subsequent hypothyroidism.
Thyrotoxicosis during radiotherapy results from excessive thyroid hormone release due to TSH suppression.
Understanding these acute effects is crucial for managing patients undergoing radiotherapy.