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Complete synthesis of 3'-sialyl-N-acetyllactosamine by regioselective transglycosylation
1Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università degli Studi di Trieste, Italy. vetere@univ.trieste.it
FEBS Letters
|December 16, 1996
Abstract:
Transglycolytic synthesis of 3'-sialyl-N-acetyllactosamine by sequential use of beta-galactosidase from Bacillus circulans and trans-sialidase from Trypanosoma cruzi was described. These reactions depicted the first complete synthesis of a biologically important oligosaccharide with high regioselectivity avoiding use of glycosyltransferases and NDP sugars.