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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
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Simian immunodeficiency virus-inoculated macaques acquire Mycobacterium avium from potable water during AIDS

K G Mansfield1, A A Lackner

  • 1New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9012, USA.

The Journal of Infectious Diseases
|January 1, 1997
PubMed

Insights

Potable water is a significant source of Mycobacterium avium complex (MAC) infection in SIV-infected macaques. This suggests water purification strategies could prevent mycobacterial infections in humans with HIV/AIDS.

Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Immunology

Background:

  • Mycobacterium avium complex (MAC) causes disseminated bacterial infections in late-stage AIDS.
  • Rhesus macaques experimentally inoculated with simian immunodeficiency virus (SIV) serve as a model for AIDS.
  • MAC infection is common in SIV-infected macaques.

Purpose of the Study:

  • To investigate the source of MAC infection in SIV-inoculated rhesus macaques.
  • To determine if the facility's water distribution system is a source of MAC.

Main Methods:

  • Used a sensitive polymerase chain reaction (PCR) typing technique.
  • Compared banding profiles of MAC isolates from animals and the environment.

Main Results:

  • Six animal MAC isolates matched an environmental water isolate.
  • Six other animal isolates showed minor variations from water isolates.
  • Identified potable water as a likely source of MAC infection.

Conclusions:

  • Potable water is a significant source of MAC infection in SIV-inoculated macaques.
  • Investigating water purification strategies may prevent mycobacteriosis in HIV-infected individuals.

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