Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perirhinal cortex involvement in limbic kindled seizures

M E Kelly1, D C McIntyre

  • 1Department of Psychology, Carleton University, Ottawa, Ont. Canada.

Epilepsy Research
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An analysis of applications and acceptances to the National Specialist Training Programme in General Practice Ireland from 2021-2024.

Irish medical journal·2025
Same author

Retraction.

Irish medical journal·2025
Same author

RETRACTED: An analysis of applications and acceptances to the National Specialist Training Programme in General Practice Ireland from 2021-2024.

Irish medical journal·2025
Same author

A comparison of surgical techniques for perineal wound closure following perineal excision: a systematic review and network meta-analysis.

Techniques in coloproctology·2023
Same author

Metastatic Lobular Breast Carcinoma of the Urinary Bladder After Eight Years in Remission.

Irish medical journal·2023
Same author

Outcomes of endoscopic full thickness resection in the colon rectum at an Italian tertiary center.

Techniques in coloproctology·2023
Same journal

Effect of immunotherapy on seizure severity and spike-wave index in epileptic encephalopathy with spike-wave activation in sleep: The value of EEG spikes in monitoring treatment response.

Epilepsy research·2026
Same journal

Genetic heterogeneity, movement disorders, and white matter abnormalities in pediatric developmental and epileptic encephalopathies: A retrospective cohort study from a National Neurodegenerative and Leukodystrophy Registry.

Epilepsy research·2026
Same journal

Comment on "Predictors of surgical outcome in frontal lobe epilepsy: Experience from a single-center cohort in Latin America".

Epilepsy research·2026
Same journal

Response to: "A critical appraisal of principal component analysis of antiseizure medication-induced hostility/aggression and factor analysis of levetiracetam".

Epilepsy research·2026
Same journal

Access to inpatient video-EEG monitoring for patients with frequent seizure-related emergency visits.

Epilepsy research·2026
Same journal

Effect of the ketogenic diet on absence seizures in rats with genetic absence epilepsy.

Epilepsy research·2026
See all related articles

The perirhinal cortex, not the piriform cortex, is crucial for temporal lobe epilepsy seizure spread to motor systems. This brain region amplifies and distributes seizure discharges, potentially causing convulsive responses.

Area of Science:

  • Neuroscience
  • Epileptology
  • Neuroanatomy

Background:

  • Temporal lobe epilepsy (TLE) involves specific cortical areas in seizure propagation.
  • Early research suggested the piriform cortex's role, but recent findings implicate the perirhinal cortex.

Purpose of the Study:

  • To summarize previous work on the piriform cortex in limbic seizures.
  • To present new findings on the perirhinal cortex's critical role in convulsive limbic seizures.
  • To investigate the frontal motor cortex's involvement in amygdala-kindled seizures.

Main Methods:

  • Review of earlier studies on piriform cortex.
  • In vivo and in vitro electrophysiological recordings.
  • Anatomical tracing studies.
  • Reversible functional lesions using cortical spreading depression in the frontal motor cortex.

Related Experiment Videos

Main Results:

  • The perirhinal cortex is strongly implicated in convulsive limbic seizures.
  • Anatomical studies show dense innervation from the perirhinal cortex to the frontal motor cortex.
  • Functional lesions of the frontal motor cortex affected amygdala-kindled seizures.

Conclusions:

  • The perirhinal cortex plays a critical role in the amplification and distribution of temporal lobe seizure discharges.
  • These circuits provide access to motor structures, driving convulsive responses in TLE.
  • The perirhinal cortex is a key node in the propagation of limbic seizures leading to motor convulsions.