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Related Experiment Videos

Coagulation alterations in patients undergoing elective craniotomy

M Heesen1, B Kemkes-Matthes, W Deinsberger

  • 1Department of Anesthesiology, Justus-Liebig University Giessen, Germany.

Surgical Neurology
|January 1, 1997
PubMed
Summary
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Craniotomy patients show temporary blood clot activation during surgery, indicated by thrombin antithrombin III complex (TAT) and prothrombin fragment 1 + 2 (F1 + 2) levels. D-dimer, a fibrinolysis marker, increased post-surgery.

Area of Science:

  • Neurosurgery
  • Hematology
  • Thrombosis Research

Background:

  • Thromboembolism poses a significant risk for patients undergoing craniotomy.
  • Understanding perioperative coagulation and fibrinolysis is crucial for managing this risk.

Purpose of the Study:

  • To investigate changes in coagulation and fibrinolysis markers during and after elective craniotomy.

Main Methods:

  • Measured plasma concentrations of thrombin antithrombin III complex (TAT), prothrombin fragment 1 + 2 (F1 + 2), and d-dimer.
  • Collected samples pre-anesthesia, and at 60, 180 minutes post-surgery, and on the first postoperative morning.

Main Results:

  • Significant increase in TAT and F1 + 2 (coagulation activation markers) during surgery, peaking at 180 minutes.

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  • D-dimer (fibrinolysis marker) showed a slight increase post-surgery, with a maximum on the first postoperative morning.
  • No statistical significance found for F1 + 2 and d-dimer changes.

    • Conclusions:

    • Craniotomy is associated with transient intraoperative coagulation activation.
    • Potential cause is the release of thromboplastin from brain tissue during surgery.