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The non-obese diabetic (NOD) mouse: an animal model for autoimmune thyroiditis
M C Many1, S Maniratunga, J F Denef
1Laboratory of Histology, Medical School, Catholic University of Louvain, Brussels, Belgium. Many
Abstract:
The NOD mouse, an ideal model for insulin-dependent diabetes mellitus, is also useful to study the pathogenesis of autoimmune thyroiditis. Spontaneous thyroiditis greatly varies in frequency among NOD colonies, but Hashimoto-like thyroiditis can be induced in two experimental models: goiter involution after iodide administration and immunization by TSH receptor, described hereunder.