Clear cell hyperplasia of the fallopian tube epithelium associated with ectopic pregnancy: report of a case

A case of clear cell hyperplasia of the fallopian tube epithelium associated with ectopic pregnancy is described. The lesion was encountered in a 31-year-old woman who presented with abdominal pain and had a positive pregnancy test. Ultrasound examination disclosed an enlarged right fallopian tube. The patient underwent laparotomy, at which time the right fallopian tube was excised. On gross examination, a firm, 1.2 x 1 x 1-cm nodule almost obliterating the lumen of the tube and an abundant blood clot were present. On histologic examination, chorionic villi were found in the blood clot. The nodule was composed of epithelial cells that formed solid and glandular structures. The cells had clear cytoplasm and nuclei without atypia. The differential diagnosis included clear cell adenocarcinoma, but clear cell hyperplasia associated with pregnancy was diagnosed because of the absence of cytologic atypia and mitotic figures. The patient has had an uneventful postoperative follow-up period of 1 year.