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Hemostasis parameters during ovarian stimulation for in vitro fertilization: results of a prospective study
C Biron1, F Galtier-Dereure, H Rabesandratana
1University Hospital, Montpellier, France.
Objective:
To evaluate the effect of IVF-ET on the hemostatic system.
Design:
Prospective clinical study.
Setting:
Apparently healthy age-matched women of the hospital staff at various stage of the menstrual cycle.
Patient(S):
Twenty-five women involved in a IVF-ET program at the Department of Obstetrics and Gynecology, Montpellier University Hospital.
Intervention(S):
Twenty-six hemostasis parameters evaluated repeatedly in patients undergoing IVF-ET.
Main Outcome Measure(S):
Blood cell-dependent hemostasis parameters and plasmatic coagulation factors, determined at pituitary desensitization, maximal E2 level, and P plateau.
Result(S):
Activation of the hemostatic system is evidenced at the P plateau, when D-dimers and fragments 1 + 2 of the prothrombin levels rose dramatically. At E2 peak, no significant modification of hemostasis markers was noted.
Conclusion(S):
The present results indicate that ovarian hyperstimulation may induce hemostasis activation at the P plateau. The role of supraphysiologic sex hormone levels on the hemostatic system requires further investigation.