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Equilibration rates in lipid monolayers

H M McConnell1

  • 1Department of Chemistry, Stanford University, CA 94305, USA.

Proceedings of the National Academy of Sciences of the United States of America
|December 24, 1996
PubMed
Summary
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Domain sizes in lipid monolayers change very slowly, depending on lipid diffusion, not fluid flow. Equilibration can take weeks, often reaching a metastable state, not true equilibrium.

Area of Science:

  • Biophysics
  • Surface Chemistry
  • Materials Science

Background:

  • Lipid monolayers at air-water interfaces form domains from binary mixtures.
  • Understanding domain size dynamics is crucial for interfacial phenomena.

Purpose of the Study:

  • To theoretically analyze the rate of change of domain sizes in lipid monolayers.
  • To determine factors influencing equilibration rates in binary lipid mixtures.

Main Methods:

  • Theoretical calculation of domain size change rate.
  • Analysis of lipid diffusion and hydrodynamic flow effects.

Main Results:

  • Equilibration rate is governed by lipid diffusion coefficient, not subphase hydrodynamics when lipid areas are similar.

Related Experiment Videos

  • Cholesterol-phosphatidylcholine mixtures exhibit exceptionally slow domain size changes.
  • Domain radii change by approximately 10^-6 per second for micron-sized domains.

    • Conclusions:

    • Equilibration times for these lipid monolayers can extend to weeks.
    • The final state achieved is typically metastable equilibrium, not true thermodynamic equilibrium.