Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Red blood cell adhesion on a solid/liquid interface

P Lavalle1, J F Stoltz, B Senger

  • 1Institut National de la Santé et de la Recherche Médicale, Unité 424, Fédération de Recherche Odontologique, Université Louis Pasteur, Strasbourg, France.

Proceedings of the National Academy of Sciences of the United States of America
|December 24, 1996
PubMed
Summary

Glutaraldehyde-fixed red blood cells (RBCs) adhere to fibrinogen-coated slides. Hydrodynamic interactions significantly influence RBC deposition, as shown by a random sequential adsorption model and optical microscopy analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute Traumatic Subdural Hematoma in the Elderly and Associated Factors that May Influence Chronicity.

The American surgeon·2023
Same author

[Treatment by stem cell therapy of erectile dysfunction of diabetic origin: State of the art].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2017
Same author

Step-by-step build-up of covalent poly(ethylene oxide) nanogel films.

Nanoscale·2017
Same author

Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?

Bio-medical materials and engineering·2017
Same author

Aging of bone marrow mesenchymal stromal/stem cells: Implications on autologous regenerative medicine.

Bio-medical materials and engineering·2017
Same author

Harnessing Wharton's jelly stem cell differentiation into bone-like nodule on calcium phosphate substrate without osteoinductive factors.

Acta biomaterialia·2016

Area of Science:

  • Biophysics
  • Materials Science

Background:

  • Red blood cells (RBCs) are crucial biological particles with unique adhesive properties.
  • Understanding particle deposition is vital in fields ranging from diagnostics to materials engineering.

Purpose of the Study:

  • To investigate the deposition process of glutaraldehyde-fixed red blood cells (RBCs) on fibrinogen-coated glass surfaces.
  • To develop and validate a model for RBC surface coverage and its variance.

Main Methods:

  • Optical microscopy and image analysis were employed to quantify RBC surface coverage.
  • A modified random sequential adsorption model was developed to describe the deposition dynamics.

Main Results:

  • RBCs exhibited adherence to fibrinogen-coated glass slides.

Related Experiment Videos

  • The study analyzed surface coverage and its variance as a function of particle concentration.
  • Hydrodynamic interactions were identified as a key factor influencing RBC deposition.

    • Conclusions:

    • A novel model accurately describes RBC deposition, incorporating hydrodynamic effects.
    • The findings provide insights into the physical mechanisms governing particle adhesion and surface coverage.