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Related Experiment Videos

Central odontogenic fibroma current concepts

D G Gardner1

  • 1Division of Oral Pathology, University of Colorado, School of Dentistry, Denver 80262, USA.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|November 1, 1996
PubMed
Summary

Central odontogenic fibroma classification requires refinement. Distinguishing between simple and WHO types is valid but challenging, with complex central odontogenic fibroma being a preferred term.

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Area of Science:

  • Oral pathology
  • Odontogenic tumors
  • Fibroblastic lesions

Background:

  • Central odontogenic fibroma (COF) is an incompletely understood odontogenic neoplasm.
  • Current classification and diagnostic criteria for COF require clarification.
  • Distinguishing COF from other fibroblastic and giant cell lesions is clinically relevant.

Purpose of the Study:

  • To review current knowledge on central odontogenic fibroma.
  • To clarify diagnostic criteria and taxonomic classification of COF.
  • To differentiate COF from related entities like desmoplastic fibroma and granular cell odontogenic tumor.

Main Methods:

  • Literature review of existing studies and classifications on central odontogenic fibroma.
  • Histopathological analysis of differentiating features between COF subtypes and related lesions.

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  • Comparative analysis of diagnostic terminology and its evolution.

    • Main Results:

    • The distinction between simple and WHO types of central odontogenic fibroma is histologically valid but requires careful diagnosis.
    • Complex central odontogenic fibroma is a more accurate term than the WHO type.
    • Microscopic differentiation from desmoplastic fibroma can be challenging.
    • Granular cell odontogenic tumor is a distinct entity, though some COFs may show granular cells.
    • Further research is needed to differentiate COFs with giant cell reactions from central giant cell granulomas.

    Conclusions:

    • The separation of simple and WHO central odontogenic fibromas remains valid due to distinct histologic features.
    • Complex central odontogenic fibroma is a more appropriate term, aligning with current WHO nomenclature.
    • Challenges persist in distinguishing simple odontogenic fibroma from desmoplastic fibroma.
    • Granular cell odontogenic tumor is a separate entity from odontogenic fibromas.
    • Further investigation is necessary for lesions with giant cell reactions and odontogenic epithelium.