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Related Experiment Videos

Evidence for secular change in Paget's disease

T Cundy1, K McAnulty, D Wattie

  • 1Department of Medicine, University of Auckland Medical School, New Zealand. t.cundy@auckland.ac.nz

Bone
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Paget

Area of Science:

  • Bone Diseases
  • Rheumatology
  • Geriatrics

Background:

  • Historical death certification data suggests a decline in severe Paget's disease of bone since the late 19th century.
  • This indicates a potential secular trend towards less severe forms of the condition.

Purpose of the Study:

  • To analyze trends in disease severity and patient demographics over a 21-year period at a specialized Paget's disease clinic.
  • To investigate changes in the presentation of Paget's disease of bone over two decades.

Main Methods:

  • Retrospective review of 1041 patients attending a Paget's disease clinic from 1973 to 1993.
  • Analysis of initial plasma alkaline phosphatase levels, patient age, and extent of skeletal involvement (scintigraphy) to assess disease severity.
  • Comparison of patient data between early (1973-1978) and late (1988-1993) periods.

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Main Results:

  • Despite increased referrals, there was a significant decrease in the number of new patients presenting with severe Paget's disease (plasma alkaline phosphatase > 500 U/L and > 1000 U/L).
  • The average age of newly referred patients increased significantly from 62 to 71 years.
  • Skeletal involvement decreased in patients born after 1926 compared to those born before 1915.

Conclusions:

  • Newly referred patients with Paget's disease of bone are presenting with less severe disease and at an older age than two decades prior.
  • This suggests a continued secular trend towards milder forms of Paget's disease, impacting diagnosis and management strategies.