Related Experiment Video

Updated: Oct 2, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Implications of the severity of retinopathy of prematurity on childhood development

H Tamai1, A Majima

  • 1Department of Ophthalmology, Nagoya City University Medical School, Japan.

Japanese Journal of Ophthalmology
|January 1, 1996
PubMed

Insights

Infants with severe retinopathy of prematurity (ROP) show delayed visual development and lower developmental quotients. Long-term monitoring is crucial for these high-risk children.

Area of Science:

  • Ophthalmology
  • Developmental Pediatrics
  • Neuroscience

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Understanding the long-term developmental impact of ROP severity is crucial for early intervention.

Purpose of the Study:

  • To investigate the relationship between the severity of retinopathy of prematurity (ROP) and childhood developmental outcomes.
  • To assess visual development using flash visual evoked potential (FVEP) and cognitive development using Developmental Quotient (DQ) and Intelligence Quotient (IQ) tests.

Main Methods:

  • Evaluated 21 children (birthweight ≤2500g) with ROP using FVEP (ages 1-3 years).
  • Assessed 73 children (birthweight ≤1500g) with ROP using DQ (2.5 years) and IQ (6-7 years).
  • Compared outcomes between severe and mild ROP groups.

Main Results:

  • Severe ROP group showed significantly longer P100 latency in FVEP compared to mild ROP.
  • The main DQ was significantly lower in the severe ROP group (99.1) than in the mild ROP group (108.7).
  • Higher proportion of verbal-performance IQ discrepancies in the severe ROP group.

Conclusions:

  • Infants with severe ROP are at increased risk for developmental disorders.
  • Long-term follow-up and multidisciplinary care involving pediatricians are essential for managing children with ROP.

More Related Videos

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Vision During Infancy and Toddlerhood01:23

Vision During Infancy and Toddlerhood

At birth, vision is the least developed of the major senses because the visual system is still structurally and neurologically immature. The retinas, optic nerves, and visual regions of the brain continue to mature after birth. As a result, newborns have limited visual acuity, or sharpness and clarity of vision, and respond best to objects viewed at close range, roughly 8 to 12 inches away.Rapid Visual DevelopmentVision improves rapidly during the first few months as infants observe and...