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Related Experiment Videos

Constitutive and inflammatory lymphocyte trafficking

R M Binns1, A Whyte, S T Licence

  • 1Immunology Department, Babraham Institute, Cambridge, UK.

Veterinary Immunology and Immunopathology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

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This study examines lymphocyte trafficking in pigs, revealing complex migration patterns. Current hypotheses on lymphocyte homing need refinement to fully explain observed heterogeneity in various tissues.

Area of Science:

  • Immunology
  • Veterinary Science
  • Cell Biology

Background:

  • Lymphocyte trafficking is crucial for immune surveillance and response.
  • Early research focused on basic lymphocyte migration, with evolving hypotheses over time.
  • Understanding lymphocyte homing mechanisms is key to immune system function.

Purpose of the Study:

  • To provide an overview of lymphocyte trafficking in pigs.
  • To detail current knowledge and hypotheses regarding lymphocyte migration.
  • To investigate lymphocyte entry into lymphoid, non-lymphoid, and inflammatory tissues in vivo.

Main Methods:

  • Utilized an inbred herd of MHC homozygous Large White pigs.
  • Employed labeled (FITC or 51Cr) and unlabeled donor lymphocytes and subsets.

Related Experiment Videos

  • Analyzed lymphocyte entry into various tissues, including models of inflammation.

    • Main Results:

    • Demonstrated constitutive lymphocyte entry via high endothelial venules (HEV-mediated).
    • Identified non-HEV-mediated lymphocyte homing mechanisms.
    • Observed lymphocyte entry into inflammatory models, highlighting the role of E-selectin.

    Conclusions:

    • Lymphocyte homing is complex and heterogeneous at both population and subset levels.
    • Current hypotheses on lymphocyte migration may be too simplistic.
    • Further research is needed to fully elucidate the intricacies of lymphocyte trafficking.