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Related Experiment Videos

Pulmonary function in obese subjects with a normal FEV1/FVC ratio

H Sahebjami1, P S Gartside

  • 1Pulmonary Section, Department of Veterans Affairs Medical Center, Cincinnati, OH 45220, USA.

Chest
|December 1, 1996
PubMed
Summary
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Obese individuals without obstructive airway disease can have impaired lung function. Pulmonary function tests (PFTs) identify a subgroup with reduced respiratory muscle strength (RMS) and low maximum voluntary ventilation (MVV), indicating lung dysfunction.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Obesity is associated with various health complications, including potential respiratory issues.
  • Understanding the respiratory profile of obese individuals without overt obstructive airway disease is crucial for early detection of lung dysfunction.

Purpose of the Study:

  • To assess pulmonary function test (PFT) parameters and respiratory muscle strength (RMS) in obese males without diagnosed obstructive airway disease.
  • To identify potential subgroups within this population exhibiting distinct respiratory characteristics.

Main Methods:

  • Prospective study involving 63 obese male subjects (BMI > 27.8 kg/m2) with a normal FEV1/FVC ratio (>80%).
  • Standard PFTs and measurements of maximum static inspiratory (PImax) and expiratory (PEmax) mouth pressures were conducted.

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  • Respiratory muscle strength (RMS) was calculated as (PImax+PEmax)/2. Subjects were categorized based on maximum voluntary ventilation (MVV).

    • Main Results:

    • Obese subjects with low MVV (<80% predicted) demonstrated significantly lower inspiratory and expiratory flow rates, lung volumes, PImax, and RMS compared to those with normal MVV.
    • The residual volume/total lung capacity (RV/TLC) ratio was significantly higher in the low MVV group.
    • MVV showed significant correlations with multiple PFT parameters, most strongly with maximum inspiratory flow rate (MIFR).

    Conclusions:

    • Standard PFTs can identify a subgroup of obese individuals without overt obstructive airway disease who exhibit more severe lung dysfunction, marked by low MVV.
    • Peripheral airway abnormalities are suggested as a potential cause for the observed lung dysfunction in this subgroup.