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Related Experiment Videos

Does age influence circulating adhesion molecules in the critically ill?

J Boldt1, M Müller, M Heesen

  • 1Department of Anesthesiology and Intensive Care Medicine, Justus-Liebig-University Giessen, Germany.

Critical Care Medicine
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Elderly critically ill patients exhibit higher plasma concentrations of soluble adhesion molecules, indicating increased endothelial activation or damage. These elevated levels in older patients suggest a greater susceptibility to inflammatory processes during critical illness.

Area of Science:

  • Critical Care Medicine
  • Vascular Biology
  • Geriatric Medicine

Background:

  • Soluble adhesion molecules are key indicators of inflammation and endothelial dysfunction.
  • Age-related differences in inflammatory markers among critically ill patients require investigation.

Purpose of the Study:

  • To investigate the influence of age on plasma concentrations of soluble adhesion molecules in critically ill patients.
  • To compare serial changes in adhesion molecule levels between younger and elderly critically ill patients.

Main Methods:

  • Prospective, descriptive study conducted over 5 days in a surgical intensive care unit.
  • Included 30 critically ill patients (APACHE II > 15), divided into two groups: <50 years and >70 years.
  • Measured plasma concentrations of four soluble adhesion molecules (ELAM-1, ICAM-1, VCAM-1, GMP-140) serially.

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Main Results:

  • All patients had elevated baseline adhesion molecule levels, with further increases in the first 2-3 days.
  • Elderly patients showed significantly higher increases in all measured adhesion molecules compared to younger patients.
  • Mortality was higher in the elderly group (6/15) versus the younger group (3/15).

Conclusions:

  • Critically ill elderly patients experience more pronounced endothelial activation or damage, as evidenced by higher adhesion molecule levels.
  • Age is a significant factor influencing the inflammatory response in critical illness.
  • Further research is needed to clarify the prognostic role of adhesion molecules in elderly critically ill patients.