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Hyperreactio luteinalis complicating a normal singleton pregnancy
1Department of Obstetrics & Gynecology, University of Cincinnati College of Medicine, Ohio, USA.
American Journal of Perinatology
|November 1, 1996
Summary
Hyperreactio luteinalis, a rare ovarian enlargement, can occur in pregnancy. This case required termination due to severe maternal complications, highlighting the need for prompt diagnosis and intervention.
Area of Science:
- Obstetrics and Gynecology
- Reproductive Endocrinology
Background:
- Hyperreactio luteinalis is a rare condition characterized by enlarged ovaries with theca lutein cysts.
- It is typically associated with elevated human chorionic gonadotropin (hCG) levels, often seen in gestational trophoblastic disease or multiple gestations.
Observation:
- A 16-year-old primigravida presented at 19 weeks with a spontaneously conceived pregnancy complicated by hyperreactio luteinalis and maternal anasarca.
- The condition led to significant maternal respiratory compromise due to pleural effusions and ascites, necessitating pregnancy termination.
Findings:
- Pathological examination of the products of conception ruled out gestational trophoblastic disease.
- This case demonstrates hyperreactio luteinalis occurring in the absence of trophoblastic disease, associated with severe maternal morbidity.
Implications:
- Prenatal diagnosis of hyperreactio luteinalis is possible via ultrasound.
- Intervention, including pregnancy termination, may be required for severe maternal indications.
- Ovarian regression is expected after pregnancy termination or resolution of the underlying cause.