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Related Experiment Videos

Endogenous fungal endophthalmitis

N Samiy1, D J D'Amico

  • 1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA.

International Ophthalmology Clinics
|January 1, 1996
PubMed
Summary

Fungal endophthalmitis is rising due to medical advancements. Early diagnosis and treatment with antifungals like amphotericin B are crucial for preventing vision loss.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Mycology

Background:

  • Endogenous fungal endophthalmitis incidence has increased over 50 years.
  • Associated with antibiotic use and indwelling catheters.
  • Ocular signs suggest fungal infection, especially granulomatous inflammation in at-risk patients.

Purpose of the Study:

  • To review the diagnosis and management of endogenous fungal endophthalmitis.
  • To highlight the importance of early detection and prompt treatment.

Main Methods:

  • Clinical sign analysis for diagnosis.
  • Vitreous biopsy for definitive organism identification.
  • Review of systemic and local antifungal treatment strategies.

Main Results:

  • Intraocular inflammation, particularly granulomatous, raises suspicion.
  • Vitreous biopsy is key when diagnosis is uncertain.
  • Systemic antifungals like amphotericin B or fluconazole are recommended for most cases.

Conclusions:

  • Prompt diagnosis and therapy are essential to minimize visual impairment.
  • Vitrectomy and intravitreal antifungals are considered for severe or refractory cases.
  • Risk factors and clinical presentation guide management decisions.

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