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Related Experiment Videos

Absorbable Adams-DeWeese caval clip: an experimental study

P Bonnichon1, P O Sarfati, P Santoni

  • 1Clinique Chirurgicale, Hôpital Cochin, Paris, France.

Annals of Vascular Surgery
|November 1, 1996
PubMed
Summary
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A new biodegradable PLA 96 caval clip effectively prevented pulmonary embolism in dogs for 7 months. This absorbable clip degraded completely within 19 months without causing inflammation or thrombosis.

Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Vascular Surgery

Background:

  • Permanent caval clips prevent pulmonary embolism but pose risks for transient conditions.
  • Teflon clips are effective but irreversible, necessitating alternative solutions.

Purpose of the Study:

  • To evaluate the efficacy and degradation of an absorbable caval clip made from PLA 96.
  • To assess the biocompatibility and thrombogenicity of the biodegradable clip in vivo.

Main Methods:

  • An absorbable caval clip composed of PLA 96 (96% L-lactic acid, 4% D-lactic acid) was implanted in five female beagle dogs via laparotomy.
  • Clips were monitored, and explanted at intervals from 3 to 19 months post-surgery for analysis.

Main Results:

Related Experiment Videos

  • The PLA 96 clip maintained shape, rigidity, and effectiveness for up to 7 months.
  • Complete degradation occurred between 18 and 19 months post-implantation.
  • Absorbable clip degradation did not induce significant inflammatory responses or thrombogenic effects.

Conclusions:

  • The biodegradable PLA 96 caval clip shows promise as a temporary solution for pulmonary embolism prevention.
  • Further studies are warranted due to the preliminary nature and small sample size.