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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Interferon expression by B cells

H A Young1

  • 1Laboratory of Experimental Immunology, National Cancer Institute-FCRDC, Frederick, Maryland 21702-1201, USA.

Methods (San Diego, Calif.)
|January 1, 1997
PubMed

Interferons have effects on many facets of immune system development, maturation, and function. B cells are a target for the interferons, causing alterations in cell differentiation and gene expression. However, production of interferons by B cells has not been widely studied. In this review I will discuss the limited literature on B-cell interferon production. In addition I will describe results obtained from a transgenic model in which interferon-gamma production has been targeted to the B-cell compartment. In this animal, B-cell development is blocked, reflecting the deleterious effects that aberrant expression of interferon can have on this cell population.

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