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[Amoxicillin and its excretion into bronchial secretion (author's transl)]
Zeitschrift Fur Erkrankungen Der Atmungsorgane
|February 1, 1977
Summary
This study shows that amoxicillin achieves good antibiotic levels in bronchial secretions in children, even without purulent discharge. Higher amoxicillin dosages correlate with increased secretion levels and improved germ influence.
Area of Science:
- Pharmacology
- Pediatric Infectious Diseases
- Respiratory Medicine
Background:
- Amoxicillin is a widely used antibiotic for bacterial infections.
- Understanding amoxicillin's pharmacokinetic properties, including its levels in respiratory secretions, is crucial for optimizing treatment, especially in pediatric bronchopulmonary affections.
- Comparison with ampicillin provides context for amoxicillin's efficacy.
Purpose of the Study:
- To evaluate amoxicillin's pharmacokinetic profile, including resorption, distribution, elimination, and excretion.
- To determine ampicillin levels in bronchial secretions of children treated with amoxicillin for bronchopulmonary affections.
- To establish the relationship between amoxicillin dosage, secretion levels, and antibacterial effect.
Main Methods:
- Pharmacokinetic data on amoxicillin (resorption, distribution, elimination, tissue passage, urinary excretion) were compiled.
- The bacterial spectrum of amoxicillin was analyzed.
- Bronchoscopic examinations were conducted on 88 children with bronchopulmonary affections.
- Ampicillin levels in bronchial secretions were measured after 7 days of amoxicillin therapy with varying high doses (3 x 125 mg to 3 x 750 mg).
Main Results:
- Good amoxicillin levels were detected in bronchial secretion specimens, particularly 2-4 hours after the last administration.
- Adequate antibiotic levels were observed even in the absence of purulent secretions or significant inflammation.
- A correlation was established between amoxicillin dosage, concentration in secretions, and its impact on targeted bacteria.
Conclusions:
- Amoxicillin demonstrates favorable penetration into bronchial secretions in pediatric patients.
- Therapeutic amoxicillin concentrations can be achieved in respiratory secretions, supporting its use in treating bronchopulmonary infections.
- Dosage optimization of amoxicillin is important for maximizing therapeutic outcomes in pediatric respiratory infections.