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[Acute pituitary necrosis after multiple pituitary stimulation test]

N Vergély1, L Millot, V Brulport

  • 1Service d'Endocrinologie, Hôpital de Bellevue, CHU de Saint-Etienne.

Presse Medicale (Paris, France : 1983)
|November 30, 1996
PubMed
Summary

Sudden pituitary gland necrosis, though rare, can occur after stimulation tests for pituitary adenomas. This study presents two new cases, highlighting potential risks and favorable outcomes following acute necrosis.

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Pathology

Background:

  • Iatrogenic pituitary gland necrosis is a known complication.
  • Stimulation tests are crucial for investigating pituitary adenomas.
  • Previous literature documents 26 cases of pituitary necrosis.

Observation:

  • Two new cases of pituitary gland necrosis following stimulation tests are presented.
  • The timing suggests a causal link between the tests and necrosis.
  • No correlation found between adenoma histology and increased necrosis risk.

Findings:

  • Sudden pituitary necrosis can be an iatrogenic complication of diagnostic stimulation tests.
  • Voluminous pituitary tumors often present with visual disturbances.
  • Proposed mechanisms for necrosis are under investigation.

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Implications:

  • These rare accidents should not deter the use of pituitary function tests in neurosurgical contexts.
  • Prompt recognition and management of acute pituitary necrosis lead to favorable outcomes.
  • Further research into the mechanisms of iatrogenic pituitary necrosis is warranted.