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Related Experiment Videos

[Carney's syndrome: 2 new cases]

B Majerus1, X Dekoninck, J C Debongnie

  • 1Service de Chirurgie, Ottignies Belgique.

Annales De Chirurgie
|January 1, 1996
PubMed
Summary
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Carney's Triad, a rare condition involving gastric leiomyoblastomas, pulmonary chondromas, and extra-adrenal paragangliomas, can present with incomplete forms. This study details two cases with gastric leiomyoblastomas and pulmonary chondromas, one also exhibiting an adrenocortical adenoma.

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Carney's Triad is a rare syndrome characterized by the co-occurrence of gastric leiomyoblastomas, pulmonary chondromas, and extra-adrenal paragangliomas.
  • The syndrome is considered incomplete when only two of the three characteristic lesions are present.
  • While 42 cases have been documented, variations and incomplete presentations continue to be reported.

Observation:

  • This report describes two young female patients presenting with symptoms suggestive of Carney's Triad.
  • Both patients exhibited gastric leiomyoblastomas and pulmonary chondromas.
  • One of the patients also presented with an adrenocortical adenoma, a less common finding in this triad.

Findings:

  • The observations highlight the variable expressivity of Carney's Triad, including incomplete forms.

Related Experiment Videos

  • The presence of an adrenocortical adenoma in one patient expands the known spectrum of associated endocrine tumors.
  • These findings underscore the importance of comprehensive evaluation in patients with components of Carney's Triad.

    • Implications:

    • Early recognition of incomplete Carney's Triad is crucial for timely diagnosis and management.
    • Further research into the genetic and molecular underpinnings of Carney's Triad may reveal new diagnostic markers or therapeutic targets.
    • Understanding the full spectrum of associated tumors, including adrenocortical adenomas, can improve patient monitoring and prognosis.