Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in plasma electrolytes during acclimatization at high altitude

D A Khan1, M Aslam, Z U Khan

  • 1Department of Chemical Pathology, Army Medical College, Rawalpindi.

JPMA. the Journal of the Pakistan Medical Association
|June 1, 1996
PubMed
Summary

Acute high-altitude exposure in lowlanders caused significant decreases in plasma sodium, aldosterone, and bicarbonate. Parathyroid hormone initially rose then fell, indicating acclimatization changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Halide Double Perovskites: Insights into Structure, Defects, and Luminescence.

ACS applied materials & interfaces·2026
Same author

Cure or Truce? Rethinking Cancer Dormancy in Modern Oncology.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

An innovative electrochemical approach for selective and sensitive urea sensing using NiNPs modified GCE.

Scientific reports·2025
Same author

A Comparative Study of Endoscopic Dacryocystorhinostomy With and Without Stent Versus External DCR.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2024
Same author

Chemical Aspects of Halide Perovskite Nanocrystals.

Topics in current chemistry (Cham)·2024
Same author

Real world data on outcomes of anti-CD38 antibody treated, including triple class refractory, patients with multiple myeloma: a multi-institutional report from the Canadian Myeloma Research Group (CMRG) Database.

Blood cancer journal·2023

Area of Science:

  • Physiology
  • Altitude Medicine
  • Endocrinology

Background:

  • High-altitude exposure affects physiological processes.
  • Acclimatization is crucial for individuals moving to higher elevations.
  • Understanding electrolyte and hormone changes is key to managing altitude sickness.

Purpose of the Study:

  • To investigate the effects of acute high-altitude exposure on plasma electrolytes and hormones.
  • To characterize the physiological response to rapid ascent to 4424 meters.

Main Methods:

  • Twenty healthy lowlander males (18-34 years) were exposed to 4424m for 96 hours.
  • Plasma samples were analyzed for sodium, potassium, chloride, HCO3, ionized calcium, phosphate, aldosterone, and parathyroid hormone (PTH).

Related Experiment Videos

Main Results:

  • Plasma sodium, aldosterone, HCO3, ionized calcium, and phosphate levels significantly decreased.
  • Plasma potassium and chloride levels showed no significant changes.
  • Plasma PTH initially increased at 48 hours, then decreased by 96 hours.

Conclusions:

  • Sudden high-altitude exposure induces significant changes in electrolyte balance and hormone levels.
  • A decrease in plasma aldosterone and PTH is characteristic of early acclimatization.
  • These hormonal and electrolyte shifts are critical for physiological adaptation to high altitude.