[Experience of carperitide (synthetic human-atrial natriuretic peptide) after cardiovascular surgery]

Recently carperitide (synthetic human-atrial natriuretic peptide) in known to be useful for the care of acute heart failure. Stretch of the atrial wall has been suggested to be on one of the important factors involved in peptide release. The 8 patients were undertaken cardiac surgery. Carperitide was infused intravenously during postoperative period in these patients and the effects of carperitide were examined. Blood pressure (BP), central venous pressure (CVP), mean pulmonary arterial pressure (PA), pulmonary capillary wedge pressure (PCWP), cardiac index (CI), systemic vascular resistance (SVR), pulmonary vascular resistance (PVR) were monitored by Swan-Ganz catheter, and urinary volume per body weight (UV/kg) were measured. The variables were determined before and after the intravenous infusion of carperitide at 0.1 to 0.2 microgram/kg/min. BP, CVP, PA, PCWP, SVR, and PVR were decreased, and CI and UV/kg were increased after administration of carperitide. These results suggest that carperitide is the useful agent for the postoperative care of cardiovascular surgery especially in the point of decreasing BP and increasing urination.