Related Experiment Videos
[A case of ASD with SLE treated with Carmeda BioActive surface circuit in cardiopulmonary bypass system]
R Toda1, H Saigenji, T Nishida
1Second Department of Surgery, Kagoshima University, Japan.
Insights
This study shows that a heparin-coated Carmeda BioActive Surface (CBS) system effectively prevents complement activation decline in patients with Atrial Septal Defect (ASD) and Systemic Lupus Erythematosus (SLE) during heart surgery.
Area of Science:
- Cardiovascular Surgery
- Immunology
- Biomaterials
Background:
- Systemic Lupus Erythematosus (SLE) can complicate cardiac surgery by increasing the risk of postoperative complications.
- Complement activation is a key factor in SLE-related complications, particularly during cardiopulmonary bypass.
Abstract:
A 61-year-old woman of ASD complicated with SLE was operated on. We used a heparin coating Carmeda BioActive Surface (CBS) in cardiopulmonary bypass circuit for the purpose to prevent the postoperative complications due to the reduced complement activation by SLE. This system could prevent the decline of the reduced complement activation during cardiopulmonary bypass and after operation. The management of steroid therapy for SLE patient, usefulness of heparin coating CBS system for hypocomplement disease were discussed.