[Antibodies to collagen type I and fibronectin in patients with scleroderma systemic ]

Antibodies to collagen type I, total and immunoactive plasmic fibronectin were measured in 39 patients with scleroderma systematica using solid-phase enzyme immunoassay. It was found that growing activity of the disease was associated with an increase in the titer of antibodies to collagen type I and a decrease in the level of immunoactive fibronectin. With enhancement of the process generalization, the titer to the antibodies also rose. Total fibronectin in patients with scleroderma systematica and normal subjects was the same.