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Related Experiment Videos

[Drug-induced hepatic involvement, something to consider!]

M K Oestreicher1, J Desmeules, E Giostra

  • 1Division de pharmacologie clinique, Hôpital Cantonal Universitaire de Genève.

Schweizerische Medizinische Wochenschrift
|November 30, 1996
PubMed
Summary

Drug-induced liver injury is a significant concern, with antibiotics being the most frequent cause. Spontaneous reporting of adverse drug events remains low, highlighting the need for improved pharmacovigilance.

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Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Internal Medicine

Background:

  • Drug-induced liver injury (DILI) poses a significant clinical challenge.
  • Accurate causality assessment is crucial for understanding DILI.
  • Retrospective studies are valuable for analyzing DILI patterns.

Purpose of the Study:

  • To analyze the incidence and characteristics of drug-induced liver injury.
  • To identify the most common drug classes associated with DILI.
  • To evaluate the reporting rates of adverse drug events.

Main Methods:

  • Retrospective analysis of 142 DILI cases over 5 years.
  • Utilized World Health Organization (WHO) and Council for International Organizations of Medical Sciences (CIOMS) criteria.

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  • Categorized drugs by therapeutic class and assessed causality.

    • Main Results:

    • 255 drugs were linked to DILI (certain, probable, or possible causality).
    • Antibiotics were the most frequent cause (43%), followed by cardiovascular drugs (20%).
    • 44% of patients experienced severe liver injury, including 9 deaths; only 10% of side effects were spontaneously reported.

    Conclusions:

    • Drug-induced liver injury is a serious adverse event with significant morbidity and mortality.
    • Antibiotics are a primary cause of DILI, necessitating careful monitoring.
    • Low spontaneous reporting rates underscore the limitations of current pharmacovigilance systems and suggest reports are primarily signals.