Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A digital model of trabecular bone

K Engelke¹, S M Song, C C Glüer

¹University of California at San Francisco, Osteoporosis Research Group, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research

|April 1, 1996

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discrepancies Between Osteoporotic Fracture Evaluations in Men Based on German (DVO) Osteoporosis Guidelines or the FRAX Score.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2022

Same author

Osteoporosis case ascertainment strategies in European and Asian countries: a comparative review.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020

Same author

Perspectives on the non-invasive evaluation of femoral strength in the assessment of hip fracture risk.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020

Same author

Effectiveness of a two-step population-based osteoporosis screening program using FRAX: the randomized Risk-stratified Osteoporosis Strategy Evaluation (ROSE) study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017

Same author

Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.

Bone·2015

Same author

Utilizing time-lapse micro-CT-correlated bisphosphonate binding kinetics and soft tissue-derived input functions to differentiate site-specific changes in bone metabolism in vivo.

Bone·2015

Same journal

From loci to cells: mapping variant function in bone and joint diseases.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same journal

The Journal of Bone and Mineral Research (JBMR) 40th anniversary celebration: the fourth decade (Part 2).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same journal

Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same journal

Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same journal

Is Zoledronic acid cost-saving in daily practice?

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Same journal

MULTIDIMENSIONAL SPATIAL MAPPING OF EXTRACELLULAR MATRIX: CARTILAGINOUS-OSSEOUS COMPOSITE FORMATION, TENDON INTEGRATION AND VASCULARIZATION DURING SKELETAL GROWTH AND REPAIR.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

See all related articles

A digital 3D bovine bone model enables analysis of trabecular bone structure. This tool validates in vivo imaging algorithms and assesses image processing impacts on bone analysis.

Area of Science:

Biomedical Engineering
Materials Science
Orthopedics

Background:

Trabecular bone analysis is crucial for understanding bone health and disease.
Current methods often rely on 2D imaging, which may not fully capture complex 3D structures.
Developing accurate 3D analysis tools requires reliable models for validation.

Purpose of the Study:

To create a digital 3D trabecular bone model from microCT data for quantitative analysis.
To establish a reference for developing and verifying 2D and 3D structural analysis algorithms for in vivo applications.
To evaluate the impact of image processing techniques and spatial resolution on trabecular bone structural parameters.

Main Methods:

A 3D microCT dataset of bovine bone was used to generate a digital 3D trabecular bone model.

Related Experiment Videos

Standard 2D histomorphometry and topological parameter analysis (node number, network length) were applied.

The influence of decreasing spatial resolution on the model was investigated.

Main Results:

The 3D model allows for both histomorphometric analysis and simulation of in vivo high-resolution CT data.
3D surface area was comparable to averaged 2D results, but 2D methods showed significant slice-to-slice variation.
Both histomorphometric and topological parameters were sensitive to spatial resolution and image segmentation.

Conclusions:

Digital 3D bone models are valuable for developing and validating trabecular bone analysis algorithms.
Analysis of bone microstructure should ideally utilize volumetric data or average results from numerous 2D slices.
The model facilitates the study of image processing effects and spatial resolution limitations in trabecular bone imaging.