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Related Experiment Videos

Theophylline revisited

G E D'Alonzo1

  • 1Airways Disease Center, Temple University Medical School and Hospital, Philadelphia, Pennsylvania, USA.

Allergy and Asthma Proceedings
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Theophylline, a long-used asthma medication, shows potential anti-inflammatory benefits. Its low cost and ease of use warrant re-evaluation as a controller for chronic asthma management.

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Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Theophylline has been a mainstay for chronic asthma management for over 50 years.
  • Its use has declined due to a perceived narrow therapeutic index and weaker bronchodilator effects compared to newer agents.
  • Historically viewed as a bronchodilator, its potential roles in respiratory muscle function, mucociliary clearance, and central nervous system ventilation have been recognized.

Purpose of the Study:

  • To re-evaluate theophylline's role in asthma management, considering recent evidence.
  • To explore theophylline's potential anti-inflammatory and immunomodulating properties.
  • To discuss theophylline as a controller medication for chronic asthma.

Main Methods:

  • Review of recent studies on theophylline therapy in asthma.
  • Analysis of evidence regarding anti-inflammatory and immunomodulating effects.

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  • Consideration of cost-effectiveness and ease of administration.

    • Main Results:

    • Recent studies suggest theophylline is beneficial for both chronic stable asthma and acute exacerbations.
    • Emerging evidence indicates anti-inflammatory and immunomodulating properties at sub-therapeutic levels.
    • Theophylline's potential as a controller medication is supported by these findings.

    Conclusions:

    • Theophylline's benefits extend beyond bronchodilation, including potential anti-inflammatory actions.
    • Its low cost and ease of administration make it a viable option for asthma management.
    • Theophylline should be reconsidered as both a reliever and a controller medication for chronic asthma.