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Related Experiment Videos

Transfer factor in chronic mucocutaneous candidiasis

M Masi1, C De Vinci, O R Baricordi

  • 1Department of Pediatrics, University of Bologna, Italy.

Biotherapy (Dordrecht, Netherlands)
|January 1, 1996
PubMed
Summary

Specific Transfer Factor (TF) treatment improved immune responses and clinical outcomes in patients with chronic mucocutaneous candidiasis. This therapy enhanced reactivity against Candida antigens, demonstrating its potential for treating fungal infections.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Dermatology

Background:

  • Chronic mucocutaneous candidiasis (CMC) is a debilitating fungal infection often associated with impaired cell-mediated immunity (CMI).
  • Standard treatments may be insufficient for some patients, necessitating exploration of novel immunotherapies.

Purpose of the Study:

  • To clinically evaluate the efficacy of Transfer Factor (TF) treatment in patients with CMC.
  • To assess changes in CMI, specifically lymphocyte migration test (LMT) and lymphocyte stimulation test (LST), in response to Candida antigens during TF therapy.

Main Methods:

  • Fifteen patients with CMC received in vitro produced TF specific for Candida albicans antigens or TF from blood donors.
  • CMI was assessed using LMT and LST with candidine before, during, and after TF treatment.
  • Immunological data were analyzed using the Chi-square test.

Main Results:

  • Specific TF treatment significantly increased positive LMT results against Candida antigens (83.9%) compared to non-treatment or non-specific TF (58.9%).
  • LST showed a significant decrease in thymidine uptake in control cultures during specific TF treatment.
  • A significant increase in reactivity against Candida antigen was observed during specific TF treatment compared to non-specific TF treatment (P < 0.01).
  • Clinical improvement was observed in all but one patient receiving specific TF therapy.

Conclusions:

  • Orally administered specific TF enhances immune reactivity against Candida antigens, as indicated by LMT results.
  • While LST reactivity showed complex changes, specific TF treatment led to significant improvements compared to non-specific TF.
  • Specific TF therapy demonstrated encouraging clinical efficacy in patients with chronic mucocutaneous candidiasis.

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