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Spontaneous lesions in aging FVB/N mice
J F Mahler1, W Stokes, P C Mann
1Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Toxicologic Pathology
|November 1, 1996
Summary
Nontransgenic FVB/N mice exhibit approximately 60% survival to 24 months. Lung tumors are common, while liver tumors and lymphomas are less frequent compared to other strains, impacting transgenic research interpretations.
Area of Science:
- Veterinary Pathology
- Laboratory Animal Science
- Oncology
Background:
- FVB/N mice are widely used in transgenic research due to specific genetic and reproductive traits.
- Limited data exists on the spontaneous disease incidence and survival rates of non-modified FVB/N mice.
- Understanding baseline health is crucial for interpreting transgenic model phenotypes.
Purpose of the Study:
- To assess the survival rates of FVB/N mice up to 24 months of age.
- To determine the incidence of neoplastic and nonneoplastic diseases at 14 and 24 months.
- To establish a disease profile for FVB/N mice for improved transgenic research.
Main Methods:
- Longitudinal study of nontransgenic FVB/N mice.
- Necropsy and histopathological examination of mice at 14 and 24 months.
- Incidence and type of tumors recorded for males and females.
Main Results:
- Survival to 24 months was approximately 60% in both sexes.
- Tumor incidence at 24 months was 55% in males and 66% in females.
- Lung alveolar-bronchiolar neoplasms were the most frequent tumor type in both sexes; liver tumors and lymphomas were less common than in other strains.
Conclusions:
- FVB/N mice have a distinct tumor profile, characterized by a high incidence of lung tumors and lower rates of liver tumors and lymphomas.
- This specific disease profile must be considered when analyzing FVB/N-derived transgenic models.
- The findings provide essential baseline data for FVB/N mouse usage in biomedical research.