Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Capillary perfusion in the brain

W Kuschinsky1

  • 1Department of Physiology, University of Heidelberg, Germany.

Pflugers Archiv : European Journal of Physiology
|January 1, 1996
PubMed
Summary

All brain capillaries in awake rats are continuously perfused. Even during reduced blood flow from ischemia, brain capillary flow is largely preserved, though slower. This study reveals brain capillary perfusion patterns.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial learning induces predominant downregulation of cytosolic proteins in the rat hippocampus.

Genes, brain, and behavior·2006
Same author

Volatile anesthetics evoke prolonged changes in the proteome of the left ventricule myocardium: defining a molecular basis of cardioprotection?

Acta anaesthesiologica Scandinavica·2006
Same author

Efficacy of sonothrombolysis in a rat model of embolic ischemic stroke.

Neuroscience letters·2004
Same author

Effects of chronic isovolaemic haemodilution on regional cerebral blood flow in conscious rats.

European journal of anaesthesiology·2004
Same author

Acid-base management--is it relevant for the study design of hypothermic neuroprotection?

European journal of anaesthesiology·2002
Same author

Correlation between local glucose transporter densities and local 3-O-methylglucose transport in rat brain.

Neuroscience letters·2001

Area of Science:

  • Neuroscience
  • Physiology
  • Microcirculation Research

Background:

  • Understanding brain capillary perfusion is crucial for neurological health.
  • Previous studies lacked detailed visualization of perfused versus existing brain capillaries.

Purpose of the Study:

  • To quantify brain capillary network density and perfusion in rats.
  • To investigate capillary perfusion during reduced cerebral blood flow and varying physiological conditions.

Main Methods:

  • Utilized Evans blue to label perfused capillaries and antibodies for existing capillaries.
  • Employed double staining techniques for direct comparison in identical brain sections.
  • Developed a novel method to examine brain capillary plasma flow distribution patterns.

Main Results:

  • Demonstrated a high congruence between existing and perfused brain capillaries in normocapnic rats.
  • Showed significant preservation of brain capillary flow during induced forebrain ischemia, despite reduced velocity.
  • Revealed heterogeneous distribution of capillary flow under normocapnic conditions, which decreased during hypocapnic hyperemia.

Conclusions:

  • All brain capillaries are continuously perfused in awake, normocapnic rats.
  • Brain capillary networks exhibit resilience and maintain flow during ischemic events.
  • Capillary flow distribution is dynamic and influenced by physiological states like hypocapnia.

Related Experiment Videos