Search research articles

Search research articles

Related Experiment Videos

UV-induced cutaneous photobiology

S Beissert¹, R D Granstein

¹Department of Dermatology, University of Münster, Germany.

Critical Reviews in Biochemistry and Molecular Biology

|December 1, 1996

Summary

Ultraviolet radiation (UVR) damages skin cells and impairs the immune system, increasing skin cancer risk. Understanding UVR

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy of BRAF/MEK-inhibitor therapy for epithelioid glioblastoma with a novel BRAFV600 mutation.

Acta neuropathologica communications·2024

Same author

[Metastatic squamous cell carcinoma on an ulcer in graft-versus-host disease after allogeneic stem cell transplantation].

Dermatologie (Heidelberg, Germany)·2022

Same author

[Terbinafine-resistant dermatophytoses and onychomycosis due to Trichophyton rubrum].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2021

Same author

High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma.

The British journal of dermatology·2021

Same author

Long-term efficacy and safety of risankizumab for the treatment of moderate-to-severe plaque psoriasis: interim analysis of the LIMMitless open-label extension trial beyond 3 years of follow-up.

The British journal of dermatology·2021

Same author

Treatment-resistant bullous pemphigoid developing during therapy with immune checkpoint inhibitors.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Area of Science:

Dermatology
Immunology
Environmental Health

Background:

Ultraviolet radiation (UVR) from sunlight significantly impacts human health, primarily affecting the skin.
While essential for vitamin D synthesis, UVR causes detrimental effects like sunburn, premature aging, and skin cancer.
Industrial activities damaging the ozone layer may increase future UVR exposure.

Purpose of the Study:

To review the effects of UVR on cutaneous cellular components.
To focus on the skin's immune system and UVR-induced cancer development.
To synthesize current literature on UVR's dermatological and immunological impacts.

Main Methods:

Literature review of experimental dermatology studies.
Analysis of research on UVR's effects on various skin cell types.
Investigation of UVR's role in skin cancer and immune response.

Main Results:

UVR affects different skin cells variably based on dose.
Mid-range UVR is a primary cause of UV-induced skin tumors.
The skin possesses an immunosurveillance system that can detect and respond to nascent neoplasms.

Conclusions:

UVR poses significant risks to skin health, including cancer development.
The skin's immune system plays a crucial role in combating UVR-induced damage and cancer.
Further research is needed to understand and mitigate UVR's long-term effects on skin immunity and cancer.

Related Experiment Videos