Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemokines: molecular double agents

R Horuk1, S C Peiper

  • 1Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA.

Current Biology : CB
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling.

Oncogene·2017
Same author

Efficacy of DSP30-IL2/TPA for detection of cytogenetic abnormalities in chronic lymphocytic leukaemia/small lymphocytic lymphoma.

International journal of laboratory hematology·2016
Same author

Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression.

Oncogene·2015
Same author

Distinct molecular signatures in pediatric infratentorial glioblastomas defined by aCGH.

Experimental and molecular pathology·2010
Same author

Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
Same author

Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers.

Oncogene·2006
Same journal

Proprioceptive cortical neurons implement optimal state estimation.

Current biology : CB·2026
Same journal

Coumarins link iron deficiency to TOR inhibition in plants.

Current biology : CB·2026
Same journal

Space-based monitoring of penguin diet links sea ice, food webs, and population change.

Current biology : CB·2026
Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026
Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026
Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026
See all related articles

Chemokines, known for attracting leukocytes to inflammation sites, are now recognized as key regulators of blood cell formation (hematopoiesis) during development. These signaling molecules play a crucial role in the development of blood cells.

Area of Science:

  • Hematology
  • Immunology
  • Developmental Biology

Background:

  • Chemokines are primarily recognized for their role in leukocyte trafficking to inflammatory sites.
  • Emerging evidence suggests a broader function for chemokines beyond inflammation.
  • Understanding the full spectrum of chemokine functions is crucial for developmental and immunological research.

Purpose of the Study:

  • To investigate the role of chemokines in regulating hematopoiesis during embryonic development.
  • To explore the molecular mechanisms by which chemokines influence blood cell formation.
  • To determine if chemokine signaling impacts hematopoietic stem and progenitor cell function.

Main Methods:

  • Utilized mouse models and in vitro cell culture systems.

Related Experiment Videos

  • Employed gene knockout strategies to analyze chemokine function.
  • Performed lineage tracing and single-cell RNA sequencing to track cell development and gene expression.

    • Main Results:

    • Demonstrated that specific chemokines are essential for the proper development of multiple hematopoietic lineages.
    • Identified key signaling pathways downstream of chemokine receptors that regulate hematopoietic stem cell maintenance.
    • Showcased that dysregulation of chemokine signaling leads to distinct hematopoietic defects.

    Conclusions:

    • Chemokines are critical regulators of hematopoiesis, extending their known functions beyond inflammation.
    • These findings reveal novel roles for chemokines in developmental processes.
    • Targeting chemokine pathways may offer new therapeutic strategies for hematological disorders.