Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histamine-releasing factors

S M MacDonald1

  • 1Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA. smacdona@welchlink.welch.jhu.edu

Current Opinion in Immunology
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Human basophils accumulate in chronic inflammation and allergic asthma. Researchers identified a novel protein, IgE-dependent histamine-releasing factor, as a key activator of these cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complications of intra-aortic balloon pump use: does the final position of the IABP tip matter?

Anaesthesia and intensive care·2015
Same author

Immunization of mice with Plasmodium TCTP delays establishment of Plasmodium infection.

Parasite immunology·2014
Same author

Hypoxia-excited neurons in NTS send axonal projections to Kölliker-Fuse/parabrachial complex in dorsolateral pons.

Neuroscience·2010
Same author

HrHRF: function and regulation.

Drug news & perspectives·2004
Same author

Methyl-CpG-binding protein 2 is localized in the postsynaptic compartment: an immunochemical study of subcellular fractions.

Neuroscience·2003
Same author

Putting policy into action.

Advances in experimental medicine and biology·2002
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Human basophils are increasingly found at chronic inflammation sites, particularly in allergic asthma.
  • Identifying proteins that activate basophils is crucial for understanding allergic diseases.

Purpose of the Study:

  • To identify novel proteins involved in basophil activation.
  • To investigate the role of IgE-dependent histamine-releasing factor in basophil function.

Main Methods:

  • Gene cloning techniques were employed.
  • The gene encoding the novel molecule was successfully isolated.

Main Results:

  • A candidate protein, IgE-dependent histamine-releasing factor, was identified.

Related Experiment Videos

  • The gene for this novel histamine-releasing factor was cloned.

    • Conclusions:

    • IgE-dependent histamine-releasing factor is a potential key activator of human basophils.
    • This finding opens new avenues for research into allergic asthma and chronic inflammation.