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Related Experiment Videos

Epitope spreading

C J Vanderlugt1, S D Miller

  • 1Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611, USA.

Current Opinion in Immunology
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Epitope spreading drives chronic autoimmune diseases by expanding immune responses to self-antigens. New evidence confirms its critical role in experimental autoimmune encephalomyelitis, a model for multiple sclerosis.

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Area of Science:

  • Immunology
  • Autoimmunity
  • Neuroinflammation

Background:

  • Epitope spreading describes immune responses to self-antigens released during chronic inflammation.
  • This process is implicated in the pathogenesis of various autoimmune diseases.

Purpose of the Study:

  • To investigate the role of epitope spreading in chronic autoimmune disease pathogenesis.
  • To examine advances in understanding epitope spreading in T-cell and antibody-mediated autoimmune diseases.

Main Methods:

  • Review of recent findings on epitope spreading in experimental autoimmune diseases.
  • Focus on functional evidence in animal models.

Main Results:

  • Significant progress has been made in understanding epitope spreading's contribution to chronic autoimmune pathogenesis.

Related Experiment Videos

  • Conclusive functional evidence demonstrates epitope spreading's major role in experimental autoimmune encephalomyelitis.
  • Experimental autoimmune encephalomyelitis is a CD4+ T-cell-mediated model relevant to multiple sclerosis.

    • Conclusions:

    • Epitope spreading is a key mechanism in the chronic progression of experimental autoimmune diseases.
    • The findings highlight epitope spreading as a critical factor in the pathogenesis of multiple sclerosis models.