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The GH/IGF-I axis in puberty

S Loche1, M R Casini, A Faedda

  • 1Servizio di Endocrinologia Pediatrica, Ospedale Regionale per le Microcitemie, Università di Cagliari, Italy.

British Journal of Clinical Practice. Supplement
|August 1, 1996
PubMed
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Puberty significantly impacts the growth hormone/insulin-like growth factor-I axis, increasing secretion and levels. Gonadal hormones also play a key role in adolescent growth, independent of this axis.

Area of Science:

  • Endocrinology
  • Human Physiology
  • Growth Biology

Background:

  • The growth hormone/insulin-like growth factor-I (GH/IGF-I) axis is crucial for growth and development.
  • Puberty involves significant physiological changes affecting hormonal regulation.

Purpose of the Study:

  • To investigate the effects of puberty on the GH/IGF-I axis.
  • To explore the relationship between sex hormones and pubertal growth.

Main Methods:

  • Analysis of spontaneous and stimulated GH secretion.
  • Measurement of circulating IGF-I, IGF binding protein-3, GHRH, and GH-binding protein levels.
  • Correlation of hormonal changes with pubertal stages and sex steroid levels.

Main Results:

Related Experiment Videos

  • GH secretion (spontaneous and stimulated) and circulating IGF-I/IGFBP-3 increase during puberty.
  • Increased GH secretion is linked to pulse amplitude, influenced by estrogen.
  • Gonadal hormones promote adolescent growth independently of the GH/IGF-I axis.

Conclusions:

  • Puberty profoundly alters the GH/IGF-I axis, enhancing growth-related hormone secretion and levels.
  • Gonadal hormones are critical drivers of the adolescent growth spurt, with effects beyond the GH/IGF-I axis.