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Oral ketamine produces a dose-dependent CNS depression in the rat
M Shimoyama1, N Shimoyama, C E Inturrisi
1Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA.
Life Sciences
|January 1, 1997
Abstract:
The oral to parenteral potency of ketamine to produce central nervous system (CNS) depression was estimated in rats using a behavioral scale. As a function of dose, ketamine produces CNS depression that ranges from ataxia to anesthesia by either route of administration. The oral ED50 value for ketamine was 120 mg/kg (82.2-159.2, 95% CI) while the intravenous ED50 value was 3.7 mg/kg (2.4-5.1, 95% CI). Oral ketamine produces CNS effects comparable to intravenous ketamine, although the drug is approximately 32 fold less potent by the oral route.