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Related Experiment Videos

Low pulmonary diffusing capacity in subjects with acute mountain sickness

R L Ge1, Y Matsuzawa, M Takeoka

  • 1First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Chest
|January 1, 1997
PubMed
Summary

Reduced pulmonary diffusing capacity in acute mountain sickness (AMS) indicates early lung issues. This suggests subclinical interstitial edema may cause gas exchange abnormalities at high altitudes.

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Area of Science:

  • Physiology
  • Altitude Medicine
  • Pulmonary Function

Background:

  • Acute mountain sickness (AMS) is a common condition at high altitudes.
  • The relationship between AMS and early high-altitude pulmonary edema (HAPE) requires further investigation.
  • Pulmonary diffusing capacity changes are potential indicators of altitude-related lung dysfunction.

Purpose of the Study:

  • To investigate if reduced pulmonary diffusing capacity in AMS signifies early high-altitude pulmonary edema (HAPE).
  • To assess pulmonary gas exchange abnormalities in healthy individuals experiencing AMS.
  • To correlate pulmonary diffusing capacity with AMS severity and blood oxygen levels.

Main Methods:

  • 32 healthy subjects ascended to 4,700 m from 2,260 m.

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  • Pulmonary diffusion capacity for carbon monoxide (DCO), blood gas analysis, and spirometry were measured.
  • Subjects were categorized into AMS and non-AMS groups based on symptom scores.

    • Main Results:

    • The AMS group exhibited a significantly lower increase in DCO compared to the non-AMS group.
    • In severe AMS cases, DCO actually decreased.
    • The AMS group showed lower vital capacity, reduced PaO2, and increased alveolar-arterial oxygen difference.
    • DCO strongly correlated negatively with AMS score and positively with PaO2.

    Conclusions:

    • Decreased pulmonary diffusing capacity in AMS suggests pulmonary gas exchange impairment.
    • Subclinical interstitial edema is a likely cause of these gas exchange abnormalities.
    • Reduced DCO may serve as an early indicator of altitude-induced lung dysfunction.