Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liver function and splanchnic ischemia in critically ill patients

N D Maynard1, D J Bihari, R N Dalton

  • 1Department of Surgery, Guy's Hospital, London, United Kingdom.

Chest
|January 1, 1997
PubMed
Summary

Splanchnic ischemia causes hepatic dysfunction in critically ill patients, impacting survival. The MEGX formation test effectively assesses liver function and blood flow in these patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Sarcoma.

The Journal of comparative medicine and veterinary archives·2022
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

Impact on postoperative complications of changes in skeletal muscle mass during neoadjuvant chemotherapy for gastro-oesophageal cancer.

BJS open·2020
Same author

Biological variation of cardiac troponins in chronic kidney disease.

Annals of clinical biochemistry·2020
Same author

Brachytherapy in the Palliation of Oesophageal Cancer: Effective but Impractical?

Clinical oncology (Royal College of Radiologists (Great Britain))·2019

Area of Science:

  • Critical Care Medicine
  • Hepatology
  • Gastroenterology

Background:

  • Critically ill patients often experience splanchnic ischemia.
  • Hepatic dysfunction is a common complication in critical illness.
  • Assessing liver function in critically ill patients is challenging.

Purpose of the Study:

  • To investigate the link between splanchnic ischemia and hepatic dysfunction in critically ill patients.
  • To evaluate the effectiveness of the MEGX formation test in assessing liver function in this population.

Main Methods:

  • Prospective study of 27 critically ill patients.
  • Measured hepatic metabolism of lidocaine to MEGX and indocyanine green clearance.
  • Assessed gastric intramucosal pH (pHim) and standard liver function tests.

Related Experiment Videos

Main Results:

  • MEGX levels were significantly higher in survivors and correlated with pHim.
  • Nonsurvivors showed a decline in MEGX levels over 3 days.
  • MEGX formation test and pHim were strong predictors of survival.

Conclusions:

  • Critically ill patients develop hepatic dysfunction associated with poor outcomes.
  • Hepatic dysfunction may result from a mismatch between metabolic demand and blood flow.
  • The MEGX formation test is a highly effective tool for assessing liver function in critically ill patients.