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Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects
1Department of Urology, Hospital S. João, Porto, Portugal.
Purpose:
Capsaicin was used to treat symptomatic patients with hyperactive or hypersensitive bladders.
Materials And Methods:
Capsaicin solution (1 mM.) was instilled into the bladder of 16 patients with spinal hyperreflexia, bladder instability or hypersensibility.
Results:
Frequency decreased in 14 patients and continence was achieved in 10 of 14 incontinent cases. Mean first desire to void and maximal cystometric capacity increased significantly. These effects lasted for 6 to 12 months and were renewed following repeat treatment.
Conclusions:
Bladder afferent desensitization with capsaicin is promising in patients with motor or sensory bladder dysfunction, although initial pungency might limit its use.