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Associations between carotid atherosclerosis and high factor VIII activity, dyslipidemia, and hypertension
1Division of Epidemiology and Public Health, Academia Sinica, Taipei, Taiwan, ROC. pan@novell.ibms.sinica.edu.tw
Insights
High factor VIII activity is linked to carotid atherosclerosis in Chinese adults, alongside hypertension and high cholesterol. Hypertension and high blood sugar also correlate with stroke risk.
Area of Science:
- Cardiovascular epidemiology
- Vascular biology
- Hemostasis and thrombosis
Background:
- Investigated extracranial carotid atherosclerosis and stroke risk factors in a Chinese population.
- Utilized data from the Cardiovascular Disease Risk Factor Two-Township Study.
Purpose of the Study:
- To assess the relationship between coagulation factors and the incidence of stroke and carotid atherosclerosis.
- To identify key risk factors contributing to cardiovascular diseases in the studied cohort.
Main Methods:
- Employed logistic regression models to analyze associations between risk factors and outcomes.
- Controlled for age and sex in statistical analyses.
- Utilized color duplex ultrasonography for carotid plaque assessment.
Main Results:
- Stroke was associated with hypertension and elevated plasma glucose.
- Carotid atherosclerosis showed significant links to factor VIII activity, hypercholesterolemia, hypertriglyceridemia, and hypertension.
- The highest tertile of factor VIIIc (> 1.53) demonstrated a 3.35 odds ratio for carotid atherosclerosis compared to the lowest tertile (< 1.20).
Conclusions:
- Hypertension, hypercholesterolemia, and hypertriglyceridemia are implicated in carotid atherosclerosis pathogenesis.
- Hypertension and hyperglycemia play roles in stroke development.
- A positive association between factor VIIIc and carotid atherosclerosis was observed in this Chinese population, warranting further investigation into its independence from other cardiovascular risk factors.
Background And Purpose:
A subsample of 147 Chinese subjects from a population-based study of cardiovascular diseases (Cardiovascular Disease Risk Factor Two-Township Study) participated in an ancillary study on extracranial carotid color duplex ultrasonography that aimed to assess the relations of coagulation factors to stroke and carotid atherosclerosis.
Methods:
Logistic models were used to study the associations between cardiovascular disease risk factors and stroke/carotid atherosclerosis, controlling for the effects of age and sex.
Results:
Stroke was significantly associated with hypertension and high values of plasma glucose but not with fibrinogen, factor VIIc, or factor VIIIc. Carotid plaques identified in this study were mostly mild and moderate. The presence of these mild and moderate carotid plaques was significantly associated with high values of factor VIII activity, hypercholesterolemia, hypertriglyceridemia, and hypertension. The highest tertile of factor VIIIc (> 1.53) was associated with an odds ratio of 3.35 for carotid atherosclerosis when compared with the lowest tertile (< 1.20). A multiple logistic regression including all significant risk factors showed that the degree of association between factor VIIIc and atherosclerosis was attenuated to an odds ratio of 2.65 (P = .061).
Conclusions:
In the present study, the roles of hypertension, hypercholesterolemia, and hypertriglyceridemia have been implicated in the pathogenesis of carotid atherosclerosis, and roles for hypertension and hyperglycemia in stroke were indicated. A positive association between factor VIIIc and carotid atherosclerosis in this Chinese population was found. Whether this association is independent of the effect of other cardiovascular risk factors awaits further study.