Jove
Visualize
Contact Us

Related Experiment Videos

Interfering contexts of regulatory sequence elements

E N Trifonov1

  • 1Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel. bptrifol1@weizmann.weizmann.ac.il

Computer Applications in the Biosciences : CABIOS
|October 1, 1996
PubMed
Summary

DNA sequences contain multiple overlapping codes, not just regulatory signals. This complexity explains why perfect consensus sequences often underperform, highlighting the intricate nature of genetic information processing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One common structural feature of "words" in protein sequences and human texts.

Journal of biomolecular structure & dynamics·2013
Same author

Towards functional repertoire of the earliest proteins.

Journal of biomolecular structure & dynamics·2012
Same author

Nucleosome positioning pattern derived from oligonucleotide compositions of genomic sequences.

Journal of biomolecular structure & dynamics·2010
Same author

Single-base resolution nucleosome mapping on DNA sequences.

Journal of biomolecular structure & dynamics·2010
Same author

Nucleosome DNA bendability matrix (C. elegans).

Journal of biomolecular structure & dynamics·2008
Same author

Sequence structure of hidden 10.4-base repeat in the nucleosomes of C. elegans.

Journal of biomolecular structure & dynamics·2008
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Regulatory elements rarely match consensus sequences perfectly.
  • Mismatched sequences can lead to suboptimal performance.
  • This discrepancy arises from the multifaceted nature of DNA sequences.

Purpose of the Study:

  • To explain why DNA regulatory elements deviate from consensus sequences.
  • To elucidate the role of overlapping codes in DNA function.
  • To explore the impact of sequence complexity and code degeneracy on gene regulation.

Main Methods:

  • Analysis of sequence data to identify overlapping codes.
  • Examination of interactions between different coding systems within DNA.
  • Investigating the relationship between code density, sequence complexity, and regulatory element performance.

Main Results:

  • DNA sequences encode multiple, overlapping messages simultaneously.
  • These codes include classical triplet code, DNA shape, chromatin, splicing, and modulation codes.
  • Sequence complexity and code degeneracy significantly influence regulatory element function.

Conclusions:

  • The performance of regulatory elements is constrained by the simultaneous operation of multiple, interacting codes.
  • Understanding these overlapping codes is crucial for deciphering gene regulation.
  • DNA's complexity arises from its ability to convey diverse information through interwoven coding systems.

Related Experiment Videos