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Published on: March 16, 2016
Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies
1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
Abstract:
Inflammatory mechanisms in the brain may contribute to the neurodegenerative process in Alzheimer's disease. The cerebral acute-phase response mediated by inflammatory cytokines, the complement cascade, and the accumulation of activated microglial cells are appropriate targets for anti-inflammatory intervention. Pilot studies showed that tolerable doses of prednisone suppress the peripheral acute-phase response in Alzheimer's disease, and a multicenter therapeutic trial of prednisone is in progress. Two other anti-inflammatory drugs, hydroxychloroquine and colchicine, are also under investigation.
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