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Updated: Jul 28, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Multidrug-resistant tuberculosis: response to treatment
S Saenghirunvattana1, P Charoenpan, P Vathesatogkit
1Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
Objective:
We investigated clinical response and mortality rates in 18 HIV- negative patients with multidrug-resistant tuberculosis.
Method:
We obtained detailed data from our hospital on patients with multidrug - resistant tuberculosis defined as tuberculosis resistant at least to isoniazid and rifampicin. Therapeutic responses were evaluated by both microbiologic and clinical data.
Results:
From January 1985 to December 1990, 18 HIV-negative patients were identified and treated. One patient committed suicide 1 week after receiving antituberculous drugs. Of the 17 patients, 10 (58.8%) had clinical response as well as microbiologic response, 6 (35.3%) were persisters during 24 months of follow-up, and 1 (5.8%) died after 30 months of treatment. The median follow-up for the patients was 87 weeks (range, 24 to 212). For those who responded well, there was no relapse.
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