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Myofibroblastoma: an unusual breast lump

K A Khamis1, D M Butterworth, R J Cuschieri

  • 1Department of Surgery, Doncaster Royal and Montagu Trust, UK.

Journal of the Royal College of Surgeons of Edinburgh
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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...