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Sulfadiazine-induced sialadenitis

B Añíbarro¹, J L Fontela

¹Department of Internal Medicine, Hospital Virgen de la Luz, Cuenca, Spain.

The Annals of Pharmacotherapy

|January 1, 1997

Summary

Sulfadiazine can cause drug-induced sialadenitis, a condition leading to salivary gland swelling. Oral challenge tests confirmed sulfadiazine as the cause in a patient experiencing parotid gland enlargement.

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Area of Science:

Pharmacology
Immunology
Otolaryngology

Background:

Sulfadiazine is a sulfonamide antibiotic used to treat bacterial infections.
Drug-induced hypersensitivity reactions can manifest in various organs, including salivary glands.

Observation:

A 50-year-old male with bronchitis developed acute parotid gland swelling and ear plugging within 2 hours of ingesting Bronco-aseptilex, a medication containing sulfadiazine.
Initial skin-prick tests with sulfadiazine and Bronco-aseptilex were negative.
Oral challenge tests with Bronco-aseptilex and subsequently sulfadiazine alone reproduced the salivary gland enlargement.

Findings:

The patient presented with symptoms consistent with sialadenitis.
Oral challenge testing definitively identified sulfadiazine as the causative agent for drug-induced sialadenitis.
Skin-prick tests were not indicative of this specific hypersensitivity reaction.

Implications:

This case highlights sulfadiazine as a potential cause of drug-induced sialadenitis.
Clinicians should consider drug-induced sialadenitis in patients presenting with acute salivary gland swelling, especially after sulfonamide use.
Further investigation into the mechanisms of sulfadiazine-induced salivary gland reactions may be warranted.

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